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Coupled with a decline in physical activityattributable to the sedentary nature of many modern occupations, changes in modes of transportation, and the rise of urban livingthis shift has led to a significant energy imbalance

Journal of the International Society of Sports Nutrition, 14 (1), Walejko, J

10.1016/j.ibneur.2023.11.002 100 Mar-BausetS.Llopis-GonzlezA.Zazpe-GarcaI.Mar-SanchisA.Morales-Surez-VarelaM

6 Conclusion DS, a severe neurodevelopmental disorder dominated by SCN1A dysfunction, exhibits profound mechanistic complexity: SCN1A mutations disrupt Nav1.1 expression in GABAergic interneurons through transcriptional dysregulation, pre-mRNA splicing defects, and voltage-gated sodium channel dysfunction, leading to impaired inhibitory synaptic transmission and brainwide excitatory-inhibitory imbalance