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Additionally, in living synapses, SVs are regenerated either directly from the plasma membrane or from endosome-like vacuoles derived from the plasma membrane (Gan and Watanabe, concentrations (e.g., 130 mM), and Cl efflux will thus contribute to increase until the Cl gradient across the SV membrane reaches equilibrium

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Sensory neuroprotection, mitochondrial preservation, and therapeutic potential of N-acetyl-cysteine after nerve injury