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Multivariable analysis with time-dependent exposure and confounders After considering time-dependent exposure and confounders identified by the DAG (Figure 2), we used MSM with the GEE approach, adjusting for age at initiation of cigarette-use, sex (time-independent confounders), income, alcohol consumption, and motivation to quit smoking (time-dependent confounders) through IPW to balance confounders across each type of cigarette-use

I am also wondering if fire curing is meant to impart some element at a specific stage in the fermenting or aging of the leaf