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While GHK-Cu works systemically, rotating injections near problem areas (around the abdomen, upper arms, or thighs) can provide both systemic and localized benefits simultaneously

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But since peptide coupling agents are described as immune sensitizers, it stands to reason that the risk even if its small exists for everyone.18 Copper peptide uglies Anecdotal reports suggest that some people may experience worsened skin aging, instead of anti-aging, after using products with GHK-Cu, a rare concern dubbed copper peptide uglies. While this isnt necessarily a safety issue, it is a (again, rare) potential negative effect of using copper peptide products

What the Science Says GHK-Cu (glycyl-L-histidyl-L-lysine bound to copper) was first identified in human plasma in the 1970s