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56,57 In conclusion, despite low intracellular free zinc concentrations, intracellular zinc signaling plays a broad and vital role in physiological functions

Nociceptive neurons are endowed with a series of receptors, such as innate immune system receptors, like Toll-like receptors (TLR), which can directly detect the presence of a pathogen and send danger signals to the immune system, for instance through the secretion of neuropeptides that activate immune cells

Oncogenes encode proteins that potentiate tumorigenesis by stimulating proliferation and regulating biological activities crucial for invasion, angiogenesis, migration, and other features of malignancy

The intestinal mucosal injury and associated changes in the intestinal microbiome provide the backdrop for the inflammatory processes