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Children with Down syndrome have abnormal metabolic profiles and show increased incidence of a large number of serious diseases including leukemia and diabetes [61]

van Ree R, Antonicelli L, Akkerdaas JH, Garritani MS, Aalberse RC, Bonifazi F (1996) Possible induction of food allergy during mite immunotherapy

For instance, in 2024, a randomized controlled trial in metastatic breast cancer evidenced the benefits of a whole-food, plant-based diet in terms of weight control, metabolic balance, and hormonal restorative effects among the patients undergoing systemic therapy

Methodologically, a lack of standardization among various types of assays (e.g., enzymic recycling, HPLC, LCMS/MS) is a source of high inter-laboratory variation and conflicting results