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In the United States, cyanocobalamin injection is an FDA-approved drug for the treatment of B12 deficiency, including pernicious anemia

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A typical FDA-approved regimen for pernicious anemia includes: 100 g IM/SC daily for 67 days Then every other day for 7 doses Then every 34 days for 23 weeks Followed by 100 g monthly for life Schedule follow-up and monitor progress Potassium levels should be monitored during the first 48 hours of treatment, as rapid red blood cell production may lead to hypokalemia and, rarely, sudden death