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After the deficiency is fixed, injections might be needed only once a month

5-Amino-1MQ has been investigated in preclinical models as a selective inhibitor of NNMT, an enzyme that catalyses the methylation of nicotinamide and has been referenced in the literature in connection with cellular energy metabolism, NAD + -associated signalling pathways, and energy homeostasis

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The investigators interpreted the findings as direct pharmacological validation of the NNMT-knockdown phenotype reported earlier in the Kraus 2014 genetic-validation study