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Changes related to fat metabolism or body composition typically take longer and are usually noticed after 34 weeks of consistent use, especially when combined with a healthy diet and activity plan

Moreover, its ability to reduce mitochondrial dysfunction in experimental models of bile acid and alcohol-induced pancreatitis suggests it could be beneficial in preventing AP exacerbations due to mitochondrial injuries (57)

Aroda VR, Edelstein SL, Goldberg RB, Knowler WC, Marcovina SM, Orchard TJ et al (2016) Long-term metformin use and vitamin B12 deficiency in the Diabetes Prevention Program Outcomes Study