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The passage of metabolites such as ATP, adenosine diphosphate (ADP), pyruvate, calcium ions (Ca 2+ ), and phosphate (PO 4 ) is regulated by controlling the transport proteins

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Furthermore, researchers noted that the use of combination therapy, consisting of doxorubicin and Navitoclax (responsible for removing aging cells), led to only a 20% decrease in the running activity of p16-3MR mice, compared to the therapy with doxorubicin alone, where this coefficient reached 50% [60]

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