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Thermal sensitivity testing demonstrated that as a group, at baseline, the subjects exhibited a reduction of function of cold detection threshold of all three regions tested, and reduced function in warm detection threshold in the foot and hand (Figure 7)

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Low NAD+ links to age-related diseases like cardiovascular issues, metabolic disorders, neurodegeneration, and cancer.[3][16] For example, in Alzheimer's models, NAD+ depletion exacerbates amyloid plaque formation and neuronal death