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Similarly, cyclic hydrostatic pressure enhances the chondrogenic differentiation of BMSCs (Ogawa et al., 2009) in a dose- and time-dependent manner, and shows synergistic effects when co-cultured with nucleus pulposus cells ( In contrast, static loading generally produces negative effects

These compounds are known to have significant adverse effects on human health as exposure, particularly developmental exposure, has been associated with cognitive deficits, neurological disorders, reproductive abnormalities, metabolic diseases/disorders, obesity, and diabetes 5

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