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3.1.1 Intrinsic pathway The intrinsic pathway is a well-characterized pathway, in which cell fate is regulated through the expression of proteins containing the BH3 domain, such as Bcl2, Bcl-XL, Bax, Bak, Bid, PUMA and NOXA (Morris et al., 2021

Harmonic restraint was applied before full relaxation of structures with a force constant of 1000 kJ/mol/nm 2

48 Initial evaluation in healthy humans revealed that oral administration of Danuglipron produced a dose-dependent increase in systemic exposure bioavailability

However, its effects in amphetamine-induced models have been inconsistent, with some studies reporting no significant effects (Harsing Jr et al