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In contrast, zVAD had a minimal effect on ibrutinib-induced cell death, suggesting that apoptosis plays only a minor role, whereas ferroptosis contributes more prominently to the cytotoxic effects of ibrutinib (Fig

They are also rich sources of important phytonutrients including carotenoids, polyphenols, and glucosinolates, which include indole-3-carbinol (I3C) (derived from the breakdown of glucobrassicin found in cruciferous vegetables) and sulforaphane (an isothiocyanate derived from glucoraphanin, a glucosinolate)

By expanding our understanding of cccDNA formation, a key factor in HBVs resistance to standard treatments, Wei and Ploss are paving the way for the development of new, more effective therapies