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could be a sign of an underlying hormonal imbalance and may need investigating

Feb 11 2021;10(4)doi:10.3390/jcm10040715 Baker M, Anjum F, dela Cruz J

Buffered NAD+ ships with a pH stabilizer (most commonly Tris) that brings the reconstituted solution closer to physiological pH (~7-8.5), while unbuffered NAD+ reconstitutes acidic (~pH 3-4) and is more often associated with injection-site stinging