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Activation triggers eumelanin synthesis via the cAMP/PKA pathway, increasing dark pigment production

DOI: 10.1053/sonc.2002.35238 32

Of these overweight patients, more than 62% were noted to have acanthosis nigricans and it was particularly prominent in the Hispanic and African American children (1)

Clinicians should carefully assess all nails for atypical features that may indicate a developing periungual melanoma and prompting a referral to a dermatologist for evaluation (Box 7-1)