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IJERPH 8(6):22652303

It also inhibited NF-B DNA binding induced by LPS in RAW 264.7 cells and prevented MAPK activation caused by LPS by inhibiting the p44/42 MAPKs in the LPS-activated RAW 264.7 cells

The translational meaning for an exogenous TB-500 fragment in humans is unknown, but it is the most-cited theoretical risk in clinician reviews of this stack and is one reason researchers exclude individuals with active or undiagnosed cancer from any informal protocol