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For example, the deletion of JA in the tomato was previously shown to reduce photosynthesis, weaken the defense ability of the antioxidant system, and enhanced sensitivity to Cd [32]

Collectively, these data suggest that signalling through DAF12 is required to maintain protein homeostasis

Because of the slow onset of action and the potential for side effects, however, 6-MP and azathioprine are used mainly in the following situations: Patients with ulcerative colitis and Crohn's disease do not respond to corticosteroids

Moreover, excessive cholesterol often contributes to an immunosuppressive environment in CRC, promoting immune evasion