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Endometriosis involves significant fibrosis, and anti-fibrotic effects could theoretically reduce adhesion formation and tissue scarring that contributes to pain and organ dysfunction

Albert DH, Goodwin NC, Davies AM, Rowe J, Feuer G, Boyiadzis M, Dorritie KA, Mancini M, Gandour-Edwards R, Jonas BA, Borthakur G , Aldoss I, Rizzieri DA, Odenike O, Prebet T, Singh S, Popovic R, Shen YU, McDaniel KF, Kati WM, Modi DA, Motwani M, Wolff JE, Frost DJ

Inhibition of cystine input inhibits the synthesis of GSH in cells to the large extent and induces ferroptosis

Immunoblot analysis showed FASN protein levels were substantially decreased in a dose-dependent manner with Chac1 overexpression (Figure 5L), indicating this effect by GSH depletion is intrinsic to hepatocytes