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M2 macrophages, due to their relatively weak antioxidant defenses, undergo ferroptosis first, and the subsequent release of DAMPs and TNF- further promotes M1 polarization, rendering macrophages a factor in amplifying inflammation

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Lee, Y.-Z

Pain in the shoulder, commonly reported by patients with PD 15 , 43 , may be the first symptom in 2-8% and may even precede the onset of motor symptoms 44