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Other in vitro studies suggest that gliadin itself increases intestinal permeability indirectly by promoting the release of zonulin, a protein that induces TJ disassembly and is present in the submucosa of active coeliac patients at concentrations sixfold greater than healthy controls (Fasano et al

Risk factors for reoperation after discectomy of lumbar herniated intervertebral disc disease

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This is why attempting to maintain constant blood levels is both unnecessary and potentially wasteful