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32106116.e6

Supports memory, alertness and mental focus

Silent allosteric modulation of mGluR5 maintains glutamate signaling while rescuing Alzheimers mouse phenotypes

PARK2 mice had significantly higher normalized concentrations of Cyt-c (4.69 0.48 SEM, p = 0.03), 4-HNE (23.64 2.84 SEM, p = 0.03), Ox-LDL (8.02 0.82 SEM, p = 0.02), AGEs (9.84 1.13 SEM, p = 0.007) and TNF- (83.89 7.7 SEM, p = 0.002) compared to Wt mice (Cyt-c 2.88 0.38 SEM, 4-HNE 12.79 1.46 SEM, Ox-LDL 4.14 0.63 SEM, AGEs 3.37 0.67 SEM, TNF- 25.14 4.0 SEM) (Fig