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Toll-like receptor signalling

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Since FM is a multifactorial disease, in which proinflammatory factors and central sensitization are currently considered to play a major role [14, 20], treatment should include pharmacological and non-pharmacological approaches

These observed sex-dependent differences have been attributed to sex-dependent metabolic alterations such as the estrogen-dependent synthesis of phosphatidylcholines 88,89,90,91