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To achieve broad protection with a single recombinant antigen, a strategy called grafting, or epitope reshaping, has been successfully tested for production of neutralizing antibodies against the six clinically most relevant OspA serotypes [Citation80]

In general, plasma cholinesterase activity falls to less than 50% of normal in mild poisoning and below 10% in severe cases

10.1016/0031-9384(80)90066-9 197 RodgersS.GlenR

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