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ROS generation increases when any key enzyme deficiency or inhibited, while high levels of cumulative ROS cause ferroptosis

Two individuals with POLG mutations had mildly elevated liver function tests before KD initiation [33, 34]

Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats