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found downregulation of oxidative stress and neuronal death after injection of the phenolic substance geraniin by the middle cerebral artery occlusion-reperfusion (MCAO/R), and OGD/R models, as well as by neurological scoring assays, CCK8 assessment, TUNEL staining, detection of cells by flow cytometry, and Western blotting assessment ( ex vivo and in vivo Nrf2, HO-1 protein expression in a concentration-dependent manner in the tMCAO model (Chumboatong et al., 2020)

doi:10.1016/j.chroma.2013.03.057 Porras J, Bedoya C, Silva-Agredo J et al (2016) Role of humic substances in the degradation pathways and residual antibacterial activity during the photodecomposition of the antibiotic ciprofloxacin in water

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Given the defects in TCA cycle activity upon FH loss [41], future treatments could also target the broad metabolic changes