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For instance, TLR2 regulates allergic airway inflammation through the PI3K/Akt signaling pathway, which is associated with autophagy in asthma models

However, due to the complexity and ethical constraints of clinical trials, it is difficult for the latter to conduct large-scale and long-term follow-up, and in contrast, most clinical RCTs aim at the validation of symptomatic drugs such as calcium, vitamin D, and BPs, while the microecological modifiers that target the gutbone axis are seldom screened

furthermore, total omentectomy as well as D2 lymph node dissection under open surgery were more frequently performed in the TG group than in the PG-DTR group

Proposed mechanisms of auto-resistance to hypomethylating agents [35]