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Neuroprotective effects of HuangLianJieDu-Decoction on ischemic stroke rats revealed by (1)H NMR metabolomics approach

The significant increase in serum ALT, AST, and ALP levels observed in rats exposed to high altitudes indicates hypoxia-induced mild hepatocellular leakage and loss of membrane integrity

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Specifically, macrophages absorb extracellular lactate, promoting HMGB1 lactylation via the p300/CBP-dependent pathway during sepsis