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10.1016/j.yebeh.2011.09.018 118 TerroneG.FrigerioF.BalossoS.RavizzaT.VezzaniA

Many users become dependent on how the drug makes them feel: euphoric, confident, and emotionally open

To our knowledge, this is the first study to perform transcriptomic profiling on metformin treated SW837 rectal cancer cells, and supports a previous study in colon cancer cells, demonstrating metformin-induced alteration of genes involved in reactive oxygen species production, cell cycle, programmed cell death and energy metabolism pathways (68)