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In other tissues, including the liver, skeletal muscle and macrophages, genetic disruption of clock genes has also been linked to changes in CI, CII and CIII respiration 6,37,38,39,40,41,42,43 , highlighting that clock regulation of mitochondrial function is shaped by cell type and metabolic state

This study shows that a new pathophysiological model is scientifically mature, as basis for a new type of treatment of depression and, probably, of other psychiatric disorders, which replaces the old reductionist model and the standard therapy, even of a combined type (pharmacotherapy and psychotherapy together), which is of little efficacy

ROS can modify key proteins involved in sperm motility, such as actin and tubulin, through the formation of carbonyl groups