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Lou et al., 2024)

Apoptosis operates through two distinct pathways: the intrinsic pathway, which is dependent on internal signaling, primarily regulated by the BCL-2 family of proteins and involves mitochondria interactions, and the extrinsic pathway, which is dependent of external signaling and independent of BCL-2 and mitochondrial involvement (Jan and Chaudhry, 2019)

Nature 510:109114 Morrison JH, Lewis DA, Campbell MJ et al (1987) A monoclonal antibody to non-phosphorylated neurofilament protein marks the vulnerable cortical neurons in Alzheimers disease

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