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10.1074/jbc.ra118.003129 213 ZhaoY.HuQ.ChengF.SuN.WangA.ZouY.et al (2015)

They will discuss the intended impacts, implications, and next steps of this project

J Lab Clin Med 2002;139:334338.ArticlePubMed 32

As for the role that caffeine has in the purported benefits of the coffee enema, drinking coffee is a far more effective method for increasing the amount of caffeine in your blood (and hence causing vasodilation to potentially send toxins from the blood into the colon, or causing increased bile acid secretion to potentially facilitate liver detoxification) compared to administering it at the other end