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PMID 12118367

535,536,537 When its Cys106 site is oxidized, it can interact with TLR4 to promote inflammatory responses

2.8 Cell surface binding, endocytosis, and downregulation of TfRs For surface binding and endocytosis of AF-labeled proteins, the cells were rinsed twice with ice-cold HEPES-buffered, serum-free media, pH 7.4, and incubated for 1 h on ice with either 500 nM hemeAF546HPX, hemeAF546HPX, or AF488 holo-human Tf

Furthermore, these glands contain enzymes capable of transforming inactive hormonal precursors , such as dehydroepiandrosterone (DHEA) and androstenedione, into active androgens like testosterone and dihydrotestosterone (DHT), thereby amplifying their effect on the sebaceous glands