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The 16-amino acid peptide is encoded by the mitochondrial genome within the 12S rRNA gene and represents an important link between mitochondrial function and metabolism

After 24 h, the G1 arrested cells were washed three times with 1x PBS and three times with DMEM:F12, 10% FBS medium, all with gentle swirling

therefore, the involvement of the Nrf2/SLC7A11/GPx4 axis should be interpreted as associative rather than causative

Despite this, in this review, we consider evidence from both therapeutic dosing and overdose studies because pre-clinical data suggest everyone would develop liver injury if the dose of paracetamol was sufficiently high for that individual