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A major challenge in these conditions, and other chronic diseases with unknown causes, is identifying the biological changes that are driving symptoms, thus enabling the identification of new treatment targets

published in American Journal of Physiology, Endocrinology and Metabolism demonstrated that physiologic reversal of leptin resistance restored deiodinase activity except in the presence of elevated reverse T3

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Data availability Upon acceptance of the manuscript, the EV proteomic datasets will be deposited in the PRIDE database (PRoteomics IDEntifications Database, References Afshinnekoo, E