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As immune surveillance decreases abnormal cells can go undetected and thrive

Activation of oncogenes such as RAS and MYC, along with metabolic reprogramming phenomena like the Warburg effect, further amplify intracellular ROS generation, establishing a reinforcing cycle that perpetuates tumor development [34]

As observed at the gene level tumor cells have significantly higher scores for glutamine metabolism genes than CD8 + T cells, highlighting their metabolic differences with immune cells [151]