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Retrieved May 3, 2025, from (Cautions that people with low blood pressure or a history of gout should not take niacin/niacinamide due to risk of hypotension and hyperuricemia

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Consequently, the observed antioxidant effects of the tested agents may be responsible for the depicted hampering in HMGB1 expression by these agents that resulted in the illustrated hindering in RAGE, which dampened the activation of inflammatory signaling, resulting in the detected suppression in the production of pro-inflammatory mediators in these groups