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Volume of Distribution Volume of distribution (V) relates the amount of drug in the body to the concentration of drug (C) in blood or plasma: The volume of distribution may be defined with respect to blood, plasma, or water (unbound drug), depending on the concentration used in equation (1) (C = C b , C p , or C u )

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Typically, intramuscular injections might be given daily during the first week, followed by weekly shots for one month, and then every month or two months for life