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How Tobacco Use Impacts the Heart Oklahoma Heart Hospital Smoking makes your blood more likely to clot, thickens and narrows your blood vessels, and leads to the buildup of plaque all of which make you more likely to have a Smoking doesn't just affect your lungsit directly impacts your heart. Every cigarette exposes your heart and blood vessels to harmful chemicals that can increase blood pressure, damage arteries, reduce oxygen supply, and How Smoking Affects the Heart and Blood Vessels StoryMD

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