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5 Circadian rhythms regulate post-IS BBB repair via the neuroendocrine system 5.1 The neuroendocrine-circadian axis The neuroendocrine system acts as a key interface linking circadian regulation to BBB homeostasis and contributes to barrier repair after ischemic stroke

Mutat Res 475:4556 Ying W (2006) NAD + and NADH in cellular functions and cell death

For example, the combination of metformin with combined oral contraceptives has shown enhanced benefits on hormonal and metabolic parameters compared to either treatment alone