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Safarinejad (2008) International Journal of Impotence Research Placebo-controlled study demonstrating that subcutaneous PT-141 produced statistically significant improvements in erectile function and sexual desire in men with erectile dysfunction, particularly in men with psychogenic ED and in men who were inadequate responders to sildenafil establishing the clinical rationale for off-label PT-141 use in men with desire-related and psychogenic sexual dysfunction

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In contrast, BTK degraders represent an emerging class of therapeutic agents that not only inhibit BTK function, but also actively induce its degradation via the proteasome

In line with these data, here we provide, to the best of our knowledge, the first description of autophagy in melanocytes and fibroblasts from non-lesional vitiligo skin and we show that this process is part of a broader metabolic program and may act as a compensatory/protective response towards the intrinsic metabolic vulnerability