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The accelerated approval was granted based on initial overall response rate (ORR) of 57% in 164 treatment-nave patients and duration of response (DOR)40% of responders had a duration of response greater than 12 months, according to the FDAs full approval announcement

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In addition, they demonstrated that the timing of melatonin administration, whether before or after the application of A, also affected the level of tau carried by the exosomes