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In breast cancer cells, specifically in GI-101A cells, the use of this proteolytic enzyme positively regulates the N-terminal kinase c-Jun and kinase 38, in addition to improving the activity of caspases -3 and -9 at 24h ( Ferroptosis is a type of cell death, also programmed, which depends on iron, and is characterized by an accumulation of lipid peroxides

Additional studies have shown that orientin, dulaglutide, and dracorhodin inhibit ferroptosis by activating the Nrf2 pathway, thereby promoting diabetic wound healing [185,186,187]

In addition, epithalon stimulates skin fibroblast proliferation and reduces apoptosis in organotypic cultures of skin cells from rats of different ages [21]

In a study conducted by Yuzhen Lu et al., GA showed anti-steatosis ability in a fructose-induced NAFLD mouse model with a hepatic qualitative phenotype