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N.FerrucciL.GorbunovaV.et al (2025)

It has been shown that deletion of T Cell Receptor Alpha Constant (TRAC), B2M, and PDCD1 in universal EGFRvIII and CD19-CAR-T cells enhanced their anti-tumor responses, respectively, against both solid and hematologic malignancies (glioblastoma and leukemia)

The reasonable reading is that cagrilintides gastrointestinal effects are mechanism-based and generally manageable with titration in the studied populations, but that manageable in trials is not the same as fully characterized for long-term real-world use, and the delayed-emptying mechanism itself carries context-specific cautions that should not be waved away