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Unlike focal disorders with a single pain generator, CLBP involves overlapping anatomical, biomechanical, and neurogenic components, including discogenic pain, facet joint arthropathy, sacroiliac joint dysfunction, and myofascial sources of pain

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Exact local H 2 O 2 levels cannot be directly derived from sensor read-out, but roGFP2-Orp1 has been shown to sense as low as 0.1 M H 2 O 2 in vitro (Gutscher et al ., 2009

Broadening the applicability of these restorative procedures and scaling up the industry of cartilage therapies would only serve to further reduce manufacturing costs, and ultimately, the financial burden on both patients and providers