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Introduction Breast cancer is the most common malignant tumor and the second capital reason for cancer death among women worldwide ( Recently, increasing evidence point out that cancer is not only a genetic disease but also a metabolic disease, in which oncogenic signaling pathways participate in energy regulation and anabolism to support rapidly spreading tumors ( Table 1 )

This sample size would provide 90% power to detect an absolute difference of 25% in TIR (assuming an SD of 30%, a type I error of 5%, and a 20% withdrawal rate) ( The continuous variables were examined for normal distribution using Kolmogorov-Smirnov test

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