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Prognostic impact and targeting of BMI-1 in acute myeloid leukemia

This is similar to the way people with substance use disorders experience a strong desire to keep using a substance to avoid experiencing withdrawal

They have been shown to stimulate secretion of peptide hormones from the enteroendocrine cells such PYY and GLP-1, amino acid tryptophan with the associated neurotransmitter serotonin (5-HT: serotonin, 5-hydroxytryptamine), dopamine and GABA (Yano et al., 2015