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doi: 10.1007/s10787-025-01840-9 236 Gmez-JimnezVBurggraaf-Snchez De Las MatasROrtegaL

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The majority of eligible studies were classified as Class C (non-randomized trials, case-control studies, or time series) or D (cross-sectional, trend, case report/series, or before-and-after studies)

The generation of these NF1-pLGG mouse models paved the way for numerous investigations into multiple aspects of NF1-associated OPG including the pathways affected by loss of NF1 (79, 84, 85), the role of microenvironment in regulating these tumors (83, 8690), the remarkable specificity of timing, region, and cell-of-origin of NF1-OPG (70, 8082, 9193)