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CrossRef Research Progress of the Relationship between Metabolic-Associated Fatty Liver Disease and Colorectal Neoplasia Advances in Clinical Medicine.2025

206 In addition, enzymes involved in the control of oxidative stress can be modulated by s -cysteinylation, as is the case for the metalloenzyme Cu/Zn-superoxide dismutase 1 (SOD1), which catalyses the dismutation of superoxide anions into oxygen and hydrogen peroxide

Reducing the expression of acetyl-CoA carboxylase 1 (ACC1) increases the global histone acetylation and gene expression by reducing FA synthesis, 283 and low-potency ACC1 inhibitor TOFA resulted in tumor regression in MYC-induced renal tumors, 284 at the same time, ND-646, a nanomolar inhibitor of ACC1, inhibits tumor fatty acid synthesis and tumor growth of lung cancer in vivo