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Whereas excessive NO and nitrosative stress may result in airway injury, GSNO is an endogenous bronchodilator associated with airway smooth muscle relaxation (79) that protects against methacholine-induced airway hyperresponsiveness (98, 261) and NF-B activation during allergic airway inflammation (244)

2 IM: intramuscular Table 4 Information about the breed, physiological status, RPM doses and sources, and duration of treatments used in in vivo studies addressed in the immune system section of the current review